Solving Nanotechnology Application Challenges

“I highly value the Microfluidizer® Machine for cell disruption. It’s very reliable, processing hundreds of liters of our diverse cell suspensions with very few problems.

My colleagues and I have used two different brands of competitive equipment, but now have switched exclusively to Microfluidics. The difference is night and day. Yields of usually difficult, otherwise poorly soluble proteins are much higher after disruption with the Microfluidizer® processor.

Maintenance requirements are also much lower now. With the competitive systems, maintenance was a constant problem and required several service visits per year. Overall, I am very happy that I switched to the LM20 Microfluidizer® processor.”

"We used to sonify our bacterial samples.  But only with the Microfluidizer it is possible for us to lyse sample sizes from a few ml up to a few hundred ml.

Additionally, our samples don't heat up that much anymore during cell lysis.

For us it is the most efficient and easy way to rupture cells in a reproducible manner, so cell lysis is no trouble anymore. We are happy to have it."

“The LM20 Microfluidizer processor offers superior lysis over traditional methods of cell disruption with an efficient system to reduce internal blockages.

The scalability of the design means that the forces experienced by cells will not change if the sample volume increases. I can, therefore, have confidence that the sample quality, yield and processing times won’t be impacted by scaling up my lab processes.

 Digital controls allow the system pressure to be set more easily and accurately compared to alternative manual processors, reducing the potential for errors and increasing reproducibility.

The in-depth user training, and easy operation and maintenance procedures have been extremely beneficial. I feel confident to troubleshoot and perform preventative maintenance without having to call the support teams - it doesn’t feel like a ‘black box’ machine.

I would recommend the LM20 Microfluidizer as an essential tool for cell disruption.”

They used a French pressure cell, ultrasonification, a glass bead mixer mill, and homogenizers to disrupt various bacterial cells until a colleague told him of a high-shear fluid processor that was much more efficient and easy to use. 

Raff tested the Microfluidizer® processor and stated: “We can process 200 ml of 1:1 solution continuously in five to ten minutes versus constantly refilling the chambers of other types of equipment over a two- to three-hour time span. 

The Microfluidizer® disrupts 99% of the bacteria cells in two to three passes versus the five to ten passes other cell rupturing equipment requires.”

"We have been working with Microfluidics for well over a decade and have multiple microfluidizers. Their technical service team is top-notch and we have complete trust and confidence in them. They always go out of their way to provide us with prompt phone and email technical support as well as fast turnaround times for on-site service visits. The technical service team is extremely knowledgeable, highly capable and very friendly. We look forward to continuing our business relationship with Microfluidics well into the future."