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APPLICATIONS

Polymer Nanoparticles

Ideal Technology for Producing Polymer Nanoparticles

Polymer nanoparticles represent one of the most innovative drug delivery systems due to their ability to deliver a wide variety of drugs and improve efficacy. Initially formulated like emulsions, a very small droplet consisting of a solvent containing both the polymer and drug of choice is formed. Once the solvent is evaporated, the polymer hardens and encapsulates the drug leaving very small, solid particles.

EXPLORE:

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YOUR CHALLENGES

Polymer Nanoparticle Formulations

Useful in targeted delivery of drug molecules to improve therapeutic efficacy, it is important to be able to control the manufacturing process. Once R&D formulations have been met, repeatable consistent scaleup is essential for larger commercialization volumes.

Polymer-Nanoparticles
HOW WE CAN HELP

Reproducible Polymer Nanoparticle Manufacturing

Our technology achieves reproducible high shear forces to control particle size giving polymer nanoparticles the ability to be terminally sterilized via filtration and controlled release.

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OUR APPROACH

Scalable and Simple to Use Technology

Microfluidizer® processors are designed to be simple to use and clean with the option of conforming to cGMP requirements.

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OUR EXPERIENCE

Technology for Polymer Nanoparticle Formulations

Our 40 years of application development and machine engineering provide the experience to help drive your product to market as quickly as possible.

ADVANTAGES

Benefits of Polymer Nanoparticle Development

Biodegradable polymer nanoparticles are an innovative drug delivery system, offering a number of benefits:

  • Delivery of a combination of various therapeutic ingredients
  • Ability to include targeting moieties
  • Protecting active ingredients from degradation to ensure efficacy
  • Control of the release of ingredients
  • Particles small enough to be sterilized through filtration

Listen to Dhruba J. Bharali, Ph.D discuss the process development for the manufacture of nanotetrac.

Watch the Webinar
FORMULATION

Formulating Polymer Nanoparticles

Key steps in the formulation of Polymer Nanoparticles:

  • Aqueous phase: the water and surfactant are combined.
  • Oil phase: the polymeric and other hydrophobic ingredients (such as actives, contrast agents, etc.) are dissolved in the water immiscible solvent.

Factors to be considered in selecting the solvent:

  • Water miscibility
  • Boiling point
  • Toxicity
  • Active Pharmaceutical Ingredients (APIs)
  • Diagnostic ingredients (such as contrast enhancers)
  • Other ingredients (such as para-magnetic particles, metal oxides, etc.)
RESOURCE

Microfluidizer® Technology for the Development of Polymer Nanoparticles

This application note explains some key formulation considerations when developing water-in-oil (W/O) emulsion evaporation processes as well as a step-by-step guide for creating polymer nanoparticles using Microfluidizer® processors.

Download the App Note
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EXTRACTION

Extracting Polymer Nanoparticles

Processing steps:

  • Prepare the separate oil & aqueous phases
  • Add oil to the water phase
  • Using a rotor-stator motor, create a coarse emulsion as a stable pre-mix.
  • Process the pre-mix using a Microfluidizer® high shear homogenizer. In selecting the model, consider the critical processing parameters of chamber type, processing pressure, temperature and number of passes.

Solvent Extraction process:

  • Allow the solvent to evaporate in a hood while mixing

OR

  • Use a solvent-exchange technique, such as a separator funnel or rotary-evaporator

By working together with your formulation expertise, our engineers find the optimal solution in meeting your product goals. Our experienced process and application engineers accelerate nanomaterials development, improve production efficiency, and train and educate personnel.

With a worldwide reputation and proven track record in creating best-in-class nanoemulsions, our dedicated and talented team has the expertise to help you achieve your target particle size and distribution curve.

RESULTS

Polymer Nanoparticle Examples

Microfluidizer® technology produces on-target particles. Particle size analysis is often used to evaluate polymer nanoparticles.

Utilizing specific analytical techniques, including dynamic light scattering, optical microscopy, and SEM or TEM, we have found that Microfluidizer® technology is able to reduce polymer droplet size significantly after several passes.

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BLOG ARTICLES

Expert Advice and Information

Recommended downloads for manufacturers looking to achieve on-target particle sizes for polymer nanoparticles.

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