Microfluidizer® high shear processors have been used for decades to manufacture nanoemulsion adjuvants. Microfluidizer® technology combines a fixed geometry Interaction ChamberTM and a constant pressure intensifier pump which means that virtually the entire batch is passed through the Microfluidizer® processor at the required shear rate. This results in small particle sizes with a narrow size distribution.
Results are repeatable and scalable from lab to production scale. Parallel arrangements of identical microchannels ensure linear scalability. Large volumes can be produced at tens of liters per minute at the same particle size and PSD as achieved in the lab.
It compares favorably to the use of High Pressure Homogenizers (HPH). These devices are commonly used for cell disruption in the lab, however, scale up can cause inconsistencies as the way the cells are ruptured changes at production scale. Multiple valves can be required, which must be cleaned and reinstalled by those with specialist training.
Users of the Microfluidizer® processors find that they are easy to use and clean. Multiple users can be comfortable with this vaccine adjuvant technology as they do not require specialist skills to use the equipment.
