Biotechnology
Meeting the demanding needs of the diverse global biotechnology field.
Microfluidizer® Fluid Processing Biotechnology Equipment
For biotech companies worldwide, successful cell homogenization begins with Microfluidizer® processing biotechnology equipment.
Our high shear cell disruption, or cell lysis, with improved protein recovery and guaranteed scaleup capabilities are driving the biotech industry.
Microfluidizer® Technology Delivers Better Results
The flexible, robust Microfluidizer® processors provide better processing results than other cell disruption methods or technologies. Our high-pressure homogenizers are used to rupture a wide variety of cells with specific shear requirements.
By precisely controlling shear, our customers are able to use the lowest pressure to achieve target cell rupture rates. In addition, Microfluidizer® technology requires fewer passes and effectively cools the product with a heat exchanger. All of these factors combine to ensure optimal cell breakage and maximum protein harvesting.
BACKGROUND
Visible Results
In E. coli and yeast applications, rupture rates of greater than 99% have been achieved with Microfluidizer® technology. In addition, we work with customers to ensure that the most efficient pressure is used for each application to balance the rupture rate with maximum recovery of soluble protein. In the case of lysis of haploid S. Pombe, we determined that five passes achieved optimal results.
ADVANTAGES
Pharmaceutical Benefits
- Efficient cell disintegration
- High protein recovery
- Scalable
- Fewer passes required
- Less time to operate and clean
- Repeatable results
- Supports multiple applications
- Faster, simpler filtering
ADVANTAGES
Biotechnology Benefits
- Bacteria
- Plant
- Insect
- Fungi
- E. coli
- Yeast cells
- Algae
- Mammalian tissue
SPECIFICATIONS
Technical Features
- High shear particle size reduction
- Uniform shear rates
- Rapid cell rupturing
- Ease of use
- Simple cleaning process
- Biopharma models available
- Effective product cooling
- Small sample volumes