Microfluidizer® Technology for
Formulating Liposomes & the Importance of Vesicle Size Control
Liposomes are amongst the most established particulate-based drug delivery systems and they can be used to deliver a wide range of drugs, genes and vaccines. Through careful choice of lipids and preparation methods, liposomes can be engineered to carry many different drugs and tuned for properties such as size, charge, membrane rigidity, surface features, drug retention and release.
Their behavior in the body depends strongly on vesicle size, administration route and composition: intravenously, they are rapidly cleared from the blood by the liver and spleen, while intramuscular or subcutaneous injection directs them into the lymphatic system, which can be beneficial for vaccines.
In this webinar we will investigate the impact of liposome size and formulation on their biodistribution and discuss the importance of vesicle size control in liposome formulation and manufacture.
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About Your Speaker
Yvonne Perrie - Professor, Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow joins Microfluidics International Corporation to discuss her liposome research performed with the Microfluidizer Processor.
Dr Perrie currently holds the post of Professor in Drug Delivery within the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland. Her multi-disciplinary research focuses on the development of drug delivery systems to facilitate the delivery of drugs and vaccines, thus providing practical solutions to current healthcare problems.
She earned a PhD from the University of London, working on “Investigating the role of liposomes for drug delivery”, and later worked at Lipoxen Technologies Ltd, where she developed liposome drug delivery platform technology.
Dr Perrie joined Aston University in 2000 and was appointed Professor in Drug Delivery in 2007. Her work has been published 120 peer-reviewed manuscripts and 5 textbooks.
She has been recognized via a range of fellowships and awards including: 50th Anniversary Chair in Drug Delivery (2016), membership of the Controlled Release Society College of Fellows (2015), Fellow of the Royal Pharmaceutical Society (2014), Fellow of the Royal Society of Biology (2012), Eminent Fellow of the Academy of Pharmaceutical Sciences (2012), the Royal Pharmaceutical Society Pharmaceutical Scientist of the Year (2012), the British Science Festival Collaboration in Formulation Award (2011), and the Royal Pharmaceutical Society Science Conference Medal (2007).
Dr Perrie is currently editor-in-Chief of the “Journal of Liposome Research” and “Pharmaceutics“, as well as Associate Editor for the “Journal of Drug Targeting” and the “Journal of Pharmacy and Pharmacology“.