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M700 Microfluidizer® Processor

Ultra-High Shear Manufacturing Processing 

Once the suitable pilot batches are achieved, scale up seamlessly to full production with one of the M700 series models.

The M700 series processors have proven to be cost-effective in a broad range of industries. Utilizing the Microfluidizer® technology, these processors deliver the finest and most uniform distribution of submicron particle size at the highest shear rates available. Emulsions and suspensions are more stable, creating superior final products.

The M700 series machines have the same high-pressure, multi-slotted fixed-geometry Interaction ChambersTM that all the Microfluidics equipment possess.  It means that identical high shear rates are imparted to product formulations as are achieved on lab scale and pilot scale machines through scalable Interaction ChambersTM.

The M7125 and M7250 models generate up to 30,000 psi operating pressure for premium results at an affordable cost.  Flow rates of 300 to 900 L/hr are achievable with the right model.

A broad range of throughput in continuous or batch mode is possible due to the fact that the machine can process at a wide range of pressures and flows.

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M700

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M700 Series

Features

Standard Features

  • Proven to be highly reliable at operating pressures up to 30,000 psi in pilot and production environments.
  • Generates the highest shear rates of any fluid processor on the market today, which results most often in achieving desired product quality in a single pass.
  • Wear-resistant Interaction Chamber™ with fixed-geometry design ensures that the entire product stream encounters equal energy-per-unit fluid volume.
  • Highly durable intensifier pumping system is efficient at ultra-high pressures.
  • High-pressure plunger seals and check valves
  • Model M7250 unit comes standard with two synchronized intensifier pumps for increased flow rates.
  • Open isolator to prevent process fluid and hydraulic fluid contact.
  • Simple, efficient electric/hydraulic drive system
  • Coned and threaded tubing and fittings
  • In-line cleaning with no disassembly required
  • All stainless-steel construction
  • Validatable for cGMP and cGAMP applications

Standard Features of the M710 Processor Model

  • Dual synchronous intensifier pump provides reproducible, reliable results.
  • Constant pressure feature is available with M710 machines operating at process pressures of 1379 bar (20,000 psi) and above.
  • Wear-resistant Interaction Chamber™ technology maximizes energy-per-unit volume of product.
  • Highest shear rates of all available competitive processors.
  • Easy in-line cleaning and simple maintenance.
AVAILABLE FOR

Pharma and Biotech

Options are available for production scale processing to meet the needs of pharma and biotech customers. A range of options are available to suit specific requirements.

The M700 Series can be designed to achieve cGMP standards. Each machine comes standard with a feed pump and heat exchanger, which makes it easy to use simply by attaching the feed vessel and collection vessel then it's ready to run.

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Basic Biopharma:

  • cGMP as specified by the American Society for Mechanical Engineers – Material Certificates for all product contact parts included in an electronic Turnover Package (TOP)
  • Surface Finish – Electropolished and passivated - surface finish of < 20 Ra 
  • USP Class VI elastomers
  • Drainability – A sanitary heat exchanger, a sanitary flush pressure transducer and pitched piping are included to ensure all equipment can be drained effectively
  • CIP - clean in place

Enhanced Biopharma:

  • Includes all of the features of the Basic Biopharma machine plus:
  • 21 CFR Part 11 Data Acquisition
  • Industrial Personal Computer (IPC)
  • Other options include - automation, conductivity sensors & mass flow meter

Aseptic Biopharma:

  • All of the features of the Enhanced Biopharma machine plus:
  • Steam in Place (SIP) for processing in a sterile environment
  • Equipment is fully automated
  • Also recipes for Steam, Prime, Run & Drain
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Recommended Uses

Models M7125 and M7250 are recommended for:

  • Immiscible Liquid Emulsions
  • Solid-in-Liquid Suspensions
  • Submicron Particle Size Reduction
  • Deagglomeration and Dispersion

 

The M710 Production Model is recommended for:

  • Stable Solid-in-Liquid Dispersions
  • Stable Microemulsions
  • Submicron Particles (Nanoparticles)
  • Deagglomeration
M700 Series

Specifications

Specifications for the M7125 model:

  • Operating pressure of up to 30,000 psi/2068 bar
  • Flow rate up to 7.56 lpm (2.0 gpm)
  • Power - 18.6 kw (25 HP)

Specifications for the M7250 model:

  • Operating pressure of up to 30,000 psi/2068 bar
  • Flow rate up to 15.12 lpm (4.0 gpm)
  • Power - 37.3 kw (50 HP) / 
HOMOGENIZATION EQUIPMENT DESIGNED FOR SCALABLE PROCESSING

Our Range of High-Pressure Lab,
and Pilot Processors

LV1 Low Volume

High Shear Fluid Processor for the smallest samples.

LV1-Angle-3 Explore

M815

For processing pilot scale and small production batches.

compliant
M815-1 Explore

M110EH

For continuous, high shear fluid processing.

compliant
M110EH-8 Explore

M110P

Laboratory models for continuous processing.

compliant
M110P-Biopharma (1) Explore
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M700 Series

FAQs

From scalability, cleanability and repeatability, Microfluidizer® high shear technology has been the leader in helping clients meet their nanotechnology needs. Our experienced engineers are highly trained to talk you through the process and address any questions you may have in purchasing a production scale processor. Learn more!

Microfluidics has a large volume of webinars that are a great resource to learning more about applications and partnerships using Microfluidizer® technology.

https://www.microfluidics-mpt.com/video-resources

Microfluidizer® technology is unique in that all the results achieved on a lab scale unit are completely scalable to a pilot or production scale unit. All models contain the same fixed geometry Interaction ChamberTM design which is what produces the linearly scalable capability.

Learn more!